Wednesday, 21 January 2009

Things Happen After Event Shock

The Daily Mail have decided to have a go at MMR again as pointed out by Ben Goldacre at Bad Science. A child has fallen terribly ill "six months after MMR jab". Ten years after Andrew Wakefield speculated himself into the headlines by suggesting a link between MMR and autism (in a press-release mind, not in a research paper), this misguided rubbish is still being presented as "science news". Actually, most of the papers now seem to reject the link and are thus in the business of demonizing Wakefield himself, as if they had nothing to do with the scare. But the Daily Mail is apparently not quite ready to take even that ass-covering step. They cite the 1998 Wakefield paper (it was a press release that actually made the claims) and I have responded, though I wonder if it will be published.

Daily Mail, please read the 1998 paper by Wakefield et al. It does not suggest anything more than a temporal connection between the MMR vaccination and the onset of a symptom associated with autism (colitis) that's a long way from even suggesting a possible connection between MMR and autism. Wakefield decided to make that particular suggestion directly to the press, perhaps because the evidence did not support him and he knew it would not be published. More tellingly, ten of his his co-authors on the 1998 paper retracted their support for that claim.
So here we have another temporal association. Thing Y has happened after thing X. And so we must assume that X caused Y, right? Rubbish. I'd imagine a whole load of things happened before this poor kid fell ill.

At this point I ran out of words in the little submission box, so I'll conclude as I would have liked.

The child doubtlessly slept, ate breakfast and breathed constantly just prior to falling ill. So far as we can actually gather from the evidence here, almost anything could have "caused" this tragedy. The likeliest explanation though, is that it was nothing we could have predicted. You write that the child had previously suffered brain damage due to a Herpes Simplex infection at the age of two weeks. Anyone who has had coldsores will know that re-activation of that virus (it never leaves us) is not a predictable event and it has never been causally linked to events such as vaccination, as far as I'm aware.

To imply that MMR was responsible for this sad event is deeply irresponsible journalism and it will doubtlessly further the anti-vaccination movement and lead to more sick kids, and probably more deaths from measles- a disease that was nearly extinct in Europe before this totally unfounded scare.

Update 23 Jan 2009: Predictably enough, my comment has not appeared on the Daily Mail article. Nor have any at all, for that matter. Given that the Goldacre Evidence Army was alerted, that seems just a little suspect to me...


quicksilver said...

And deeply IRRESPONSIBLE for a doctor to vaccinate a child that has been dangerously ill and with this latent microorganism that will get every chance to run rampant when vaccination lowers the immune system.

Why don't we use contraindications used a generation ago.

Today its one size fits all and if they are well enough to get into the doctors surgery they are well enough to get the vaccine.

Often the nurse vaccinates and the doctor chacks the baby AFTERWARDS.

The Biologista said...

Vaccines weaken the immune system now? Odd that, I was under the impression that they primed new responses. That they stimulate innate and adaptive immunity, which is the point of the exercise.

If there were an argument for the involvement of the vaccine in this case, it would surely be that the vaccine had inadvertently triggered a cytotoxic response against the latently-infected brain tissue. Quite the opposite to your suggestion. Still, there does not seem to be evidence for this. Certainly not enough to jump to the conclusion that a life saving vaccine is dangerous.

So far as I am aware, latent herpes infection (which exists in a huge portion of the population) is not and never has been a contraindication for MMR inoculation. So I'm not sure what you're referring to on that count.

Berk said...

"this latent microorganism that will get every chance to run rampant when vaccination lowers the immune system."

Citation needed.

Sharon said...

Good post and to the point.

Perhaps it was that the child chewed a plastic toy, or a wooden one, or petted a dog, or sucked her thumb, or watched TV, or travelled by car, or lived near a mobile phone mast or...

How can the Daily Fail justify such speculative nonsense? It's dangerous.


Good post. This is a very nice blog that I will definitively come back to more times this year! Thanks for informative post. I am sure this post has helped me save many hours of browsing other similar posts just to find what I was looking for.
There are many brand from France, also including herve leger, and most of womens stars love wearing herve leger dress when they join in some important party. Now polo ralph lauren is very popular with youthful people, everyone want to get ralph lauren polo shirts, there are lots of online shop which are ralph lauren polo outlet, true religion jeans outlet, it will be convenient for us.